ae SyntHeTic NAMED REACTIONS. Cymigerc Ofilty) ae geportore A, Comed veactens @ C-€ bord fermaken- oy tha Kea aa Ae Cs, (0ustg) enol qpeup, @ o-c wend fPrwosion bry sedenceavEssen of Parc 0, 4g S gh gb se ng“ Bi gece ca cHo \ Alle Condeesaton — FOERME putomaldeyte TB) C-c bend Femmchion ey FG. oddtter- eg: Eriedal croft anytoken. a a a ROOK fre* ee + fo Aleg Lar Rewer Tesaer eee ca . + Cd Ao-KEN CHR, Oo CAC atCKEH —> + o Go Fondieral qcup ettrtinekion. £22 @ elemonsen Reduclon e) i) HHLN IBY (porte evcichos) © CoG SrkGorartion 1 ware, Cr Cao recess © ee hondira hoalloese} by ayelssakion, C4 DR mls dum K+ 4, OOeyapERD REAC iON @ oblesmotive. te Ltt weacken . Fy sock TENN NH 2 TS Tesyl oi pawotelyl suifernit Fey | hadhragin® t S uso 5° 4 Bs 5 Taya ag Xe we, Crest pepent) oe - HE. Bscen nets ae + HY nats ; \ Tesh Wppreasene > Commsion ob — Toeyh Wagragene of cofism® dong hang. esualed ah & Sto cletivg Proihe, peesede sh excenk ob 2 chord bose askyt (egucy 5 LDR sietires Ro,- oR RSH nae Slee. , ; @ cHaens —Pebsaneiagene Atoatne PRS) eters ® Tee tu . na) @ pme (PR metho @fRana) (reo 7 ® RY “3,8 a” fous @ LOR ( Lekrun Ricopopyl ares) Nh TS «oy ia cy +N Te eH AS ° poe NN ees y+ wate ah 58 en va, £2 <6 ee J? ee aa or tae AEE AS a os eduLee Chel 1s S ? curtitenessy fe poms TST si a cok 6 co oe ? ecoss ORG? exces, Oe me ee ky ewe 18 a” Pe F Regio ectectivity et HY E-Caty, ag “PAHS Caer tyon . A mL Dehir chenteat Samy hich Predvies wpesrel amouilt Speed Seu5 ‘gomers Callea) Regio Sele ofirily - nthe Cane eb Une qmmetecert Tetyllyghhegoncs PredomfncBley douse eng» Pretec od (was Subs tutpatel 9 —pr@ition . N-wn-TS cue ye cde iS ons cH b : : . eS YI +. my Colusa) omens) | wind — ojd 7. = A! Fai. a nkUtt excoss a& ye? Os 7 © a cha TS OAK OrR the me -napor mindx CS eet (exes) Cestes8) ay x ES eer gibeieel IM op [prbutodiene * $x, iow, sum, 3 a NTS Pal "3 z @ somieen — Sevens = Rew ens) Conwetion ob Tos hychiagone oy Cabrtonf ce wpe Sado Glef Pos, 8 He presente less cheagee hasts, neu, nant, Naost e. One Cole BAIEDRD - STEVEN'S Ax, pacome, ‘e —s 4 HOLE Ce sees 7 ne we 7 Bowe OE Ls, ale SanD ESCBENMOSER TANABE _ FRAGMENTATION? i ea ee Cemansion oF ceprBIory sy higtongons irks AthynylMtares bm bose we wessse ov neutal Guditions Catlel CecHENROSER—TmVnee, —froqmtnihn ong eTy toby hep oxen poscconed ef Combo! Coupe Ota Alkyl Ketones, (rttchaeles) ae = ak oss S Q ants t ad i “ , = —_— ce [ne smnthindon cco 6 *} i etch A NEN TS % R & Ron py TR R' *) e # met A ae £ Vw ERTS pag foe ao a ne Coie? a ‘ ‘ 4 aR Bum ae Non <8 gq aR? & A } 3 8 cg i $3 cal eo ey amayer MULAN REACTICS — (ynea TA) te Wa | (i nial q es: Ay 82% epopee 1 da ps @ 6 _ = ae’ Ay oe (monrray 2) KY, eg ‘ eames oo 3 A, m ree ae py (eayuis- one ( a. ae ade Try 186%, MORITA cleetoped fellovotg fey —O “hes disadtautage oF chs Fan EG loo 7 yetids CAB) : LEPYLIC-WILLMA WW medsbaed moire 2 the secplaciaing —S yeshpunes Ft Pupmings, the yf lgeltde ch reduc; ome fyerased. .@) Comesting & achvated clebay Mis Hytrary anew adducts by dualegeg A MB CHC bend) at oc position of Alef ane} Costony| Com te PUG 4 Fholnes called BAYUS “HICLEgW Fey. -D ° 8 dennting ary : 7M sf a ey a: (aeivatel \ Ir adlot ing ilefine othe) ty PG Called achvaial clefing pw . pen ove rire ALIBI [AROMATIC Pili boxe cemmen) mts Se QUINUQUIDNE , Common BAYLIC-H/LLeneniN ’A PPO or As = Ky 4 las, Vy dasa tSuseloL2 > 2) octame Gadquclidene sy Be 0 . D mrehacl-cda ®@Aldel tyre @ Elormatien B_peofoes (DABCO, Guirucleetine) ang Nucleophille catalyst 4 RONG +478 DABCO A, A ' ren. a oR P60 ' ie “6 8 pte) Page RES eR aro res Sniteamedicde | Alte madieny ° cn aoe B se pnt as a meepeelo SN is parece x, page Ww ae ® ok + poe ® at CHo Tt fovwee Ae,0 PASCO — 6 pare ate e. rE hen. wR ten rae) yt a Che, Fo ont WW pe Be JYL -REAETION (UCR) ——— UBT - Ae tw ome POT Sythesie eoithour ‘selating Goteamed fo mul tep Mo Gp Th Conpleted at ontstep by laKieg oft myhe — Qprropriakk Stace material calted one por Systheciy, LGlsen & I. Gapo nent one por Sutter's, 4 CNR? 2 Ashe cae oa, co CN—CH, > he on ¥% = x any te way a % Kn ~88o + ec. F Aptos may be Pad oP amine 4 AN -typee of eceyonbides FE Cosceony! Compd roy WE aldebaple aL Keone « % Cosboutc 244 iS rarcleegidthe Got 1 Even eles. PF canbe usd eg's the, oleekel Rn, RNECEO Hn EE He Th Hake, nitrates + clays. piechanin !~ eee wt an sig + tend! Se & wha + ee) 2 gp Re oe « h Cane ! TLeoqne @ . , Xe s BLETEDD EAA ondeDo Ake qoce qloce A ACaC gy Th AlGchele aru “Taken. 7 ra one ee - gt mM . @ 1 = eae =* > coh Se a 62h fe ~< m g caked Rsi & 5 ope Carn M0 8 #4, RRA es rage Rae ck ¢ R MITSUNCBD Ren LY ) —_—— XK, BON ON ——— Fk R SU PEAD, Pg? P elcehet nucleic, Cub? of FS Pf alewho by Using Car’ ack fe called MARS UNOSD DEAD, Phef rerth Fovenssion of Conbiguratien Ral. ®B pick Pore pe tin ccith FalCohels. ‘dre. nd we) Weakly atidic muctecsbis. REN (EB, pity, 1 RECA Ns TE ree +) Shaws to dy Fev oe ehehe | pom) eme D Tomparatre 025% . x : ) Bere ome Sor ture DEAD Cp ety ASO Weeeteryleie) rh nen Bosrethonitn + \ v4 = a Pht “ ° ° Atay Pe 0 e wr Fig ose og ¢ ok isn) Aon pe af oe a eel R RI rysenge Ypceeh fickvadah atechel« we i Teyersion a4 7 gig AA 4 oo DEAD jk No, ® e aa ls s ny a : \\ ee \\_ sere oS eres ace | ue pe, - Ra pres peetw, “tg, -BH = es Ze ae CGM ” “DEAD, Tha? z e™~ oS) AA Ss ‘ ACO fete ioeP Zz \ , ee aoe BLoO A OLEFINS — co@mations G Me MORAY — courting ® Torin Ly THESE ever vation @ PETER Sen's OLEFIN ATION: Soaps D Memonny eooremg = Lv) : yw Te sre R Rg ‘ Bae ts — —< AITIOS Saalug on mesa! reatic 6 al MAP) THO En- Cy This 5 Reduce Conplin, ck Cantony! Compas Ser ctefing wh Stel, & arieky and rcluctng ages cqued memussy coupleg *) Solvents THE, DME, LG DIOXANE At bow temp. Competahve produdlh piacels. H malty subverted clebtmes easy te prepre (Coupare voit) CA, of Rebra Subbed - - © eck Selectviby % dlebtr fSmatlion Cease gclectvutty eal perk.) 8 Bote oldeby ces Satter Undeage snc WARY Courting ba alddacle pare Faskes thon Kormes, Bh molecule having aldebyde & neinpenchin feleckuely aldehyde Sawer rm memorey COUPLING chemoselective San Ua Cougl % geductng eget anc - Lathe, , Lefual ng en, +) bn-04 » Last ane whe Comme Su has, AS "Noe ‘Tes + 20 / 14 R Lenton, & >‘ o Fry + L80\Ry PTH Le vale retain Redating aoa Comah “Marler hatides “ute Cer vated TY which B Tee gpected “Genversin of aw Sec SEC S ° < ck E- (ers) TULIB- Laas "t N ove priacatiaty Srtfoncs, classical F lea. -tathgec Any | Goorrescion of Pracylay Sulfercs Moto oleking Tn presen of nal hg H He+ SOL > DH RMy E-Sttheo SlecKue Fey D bowh tnemcaye fo branching at alkyl gre alebinc E-Seleckvity frerety W Nakone eb gps on Pracyiensy culfones sit net Snftucnce E-Sélechuity ay “the, aeachon (6 -preduc erly enforcing) “ey tel ee ¢ e / 9) S. Qs Sta An Lay ee Ere “Ls (rothenismy MO as oe a) ke ~irg BPs ae B® ee hp awseee of BAIO ottwea) Lp ak jee yh + ae oe ETERSON' Ss OLEEINATION > oe vo. Qiaee, ‘desankver of States) “ o ik \ Conversion of Casteni Conpae frbe olefins by treobiag With JHkKo AL mageste denwvatier oF Glace ene called peveRsons defray : ” i Qe ol . La ee, go-cHecH R Re Se eo ign Sve licen. esiton Fudemediate , PMG, —OF ‘Srl Baul mes SiC Site, Hex mela) di ciovene. daw belting bautd Fou te Remove FO) npn Tate paeesers ebivaten een wetl lieve tao bly tegead Cay © vrenove froin Rev Relating etek, fb pore Poem , ASO Bont 4 taittic Aon the Be preckuce fara (ost PreBpltreus ode) insdble o> cst getbioutt te Atmore, foe TH ick re ‘ :Pan rtormation b prtyhonybton: hich detompeses to base eractdzc 67 spertancersly tate elebcns, The Stevo Setethuty tbe Fabutting elcbin cageudt on rndane of ailaalonntns te. Biheptrny Mian Tehooweicl, auch Ponancthtey Dhak meen wehettsa, aesdse &¥ bnsiC) Seo datos to sleMeris slebicarien = . R o ‘ pina K iat . . Ke, yy mee, [aise aa : vet? 2 ~The ea ent 2 Conshtuberall) os BSRy wont AC ny tine CAinatereomeyy Fp bate madiien Syn elevation pred onfOs - Tn Audie 1 aati eltminakion predominates .( 6 - ei inatiartinn) DEAS MEDIU etree! of ERIS - AMIE PHEDILM ELIRMAMTION OF ERYTHROq wees » “pnt x “aoe va Bw . ebmfination \ + poets Troms olefin Bynes pen Ce-aukenc) Trausitior Male + woh BM FRE Exythro Wh bosic enedttum ca& Caterer mach. Tn HEwE ysdiue cane & Eons UO wnat J THREO DIOSTERCOPER R eo) Si, Syn) fe mast) 4 wa A | “Ths 208 | ors: Q ANT) maj ete CE)4 § a g@ia sng-cn > s wee ON 5 ms y rewanctd 6 & Sime, Sith ened Hes Aidahydes and Gly enet > oh NS! = Ys! the 7 yg * WN PaR Cope Rody -BLtypes- ce debke Cope Cope RA al) {) & ar 85 Shaft odes, Hasepl,TEN commies Chase Soke fe Sun MORES Ane te Aecvease Ayousitien Stade eneagy. Ke 6 \ S Be, OO ay As yg \ i oo wat\ 3 we ae ae Sra > Boia. cope RA Be Ope RA is Cake Called Os ASG Claten RD ATA WITTIG, RxN +L) Se wert) — = BR es att vg hy, ro + Phere an By : Pre Pan Fal ylide. mangas ogi sone PesThevBiy ar tera ou Convessien of Cantons, Congas, wt Tete, oY Schiff 'S beves calltdnes with Taine fabBOaS ox manytiten called —Aga Witig- A, See tire oro pen +, ered gqed prhpanR oT? en + They=O Phat T PhePEN—CH, phecon-tis, + PhyP=o qeuatts ase TOE TRE PORATION OF AEP XLIDE ‘pr gon, MSL ptereae +o? ; e-PD La Dyke RNa oo Rl oN 4 PPE Qe enh -@ aveprhy ewe “A" AZA-WITTIG MECHANISM ee ey &m fos » 4-pPhy ero ao pau —. teh Fr ‘8 rob R b k eee pn ay ig,Bedh sigmerenle SHE Olly) alkyl Bamires Ante auyl amines Fy Beaic mekum carted [4D PERN peeshonge wee C Q =ConPLEKES PACED “NOME REACTIONS Pee, ral complencs ae widely ened -fe® genic stypibta ne poe AD, pg REP HGR - ra 6, og aed pag Conglones ved be ongpee ceyntbess fin extdosiens dosent & by Ateanefering two %, (two E? -transfu, pd- Pe) PA Compbexis ase used HR C—O CH, CHO bording awd. Cheowage of CC CN, C=C, CoD These OC used feS Hyeory eyplycis - Tes-cne vaeq fT ReHo, HELO, Chomoselectivity . FE So70y| -comm jens WA) ¥ yecn- cee PLING Jes w) % STEELE fo 4) 4 Bucnwntcunnue Oye wv) % Sonoatenirrcecrn, (Vv)pa? ee of bgowd. & dur Farvanie, (Pry ery Pes) Partlgattom (©) ® ra (dba), dae Rlegy idlire Acetone TVs, (dt bevigytitine acetone) At pallastun Co). ® rai a B. — reiCoAd, pallodium Aractate. e [rtcreta,c, Paltadtiom Couples Ove VER Kakle species Crwidely used) | palledtun SM plexes Aece cetolybe mediuce Fo orgasic Syntteds SUZOK | —COUPLING, BUCO scourlng pee Ree > RR (SEP Ot ae Reg akeh IRB! erers ugly pew + Roy, THe gst : ‘4 PALy | Bose. » Fer Re Aly 5 Blkynyt, elke Aryl), Athy! AA or POR ee Ke Hale el aT Azoth < Tepblats oh CF (Teefudio matione Sulfate) Rie prey, Aukeayl, Awyrys A AEeyl NE DSR ee am aos, eye tt ye R Ye Sait geben, _ Bdeicadd, Redoute estes NowSeweute = Stherg C2 Bergene BRSE © wate 60%, Hert, NESE etc.- eer Be a, SH QYe|reoest- Recetas Rag Rr gt chara clestctics DAN the Stastfag moderiale on8 Ready arailarle & ehecret- cacy to hardle. Gt @|AV the Componadt gee menteeic , ® wigh “/- yettde (Be tosey,) F Casy ty remove bspreducrs B deste dhemitey ‘eotiats, ‘Tretétinad fo te product ® 8 = 00 @ ee te ne =e Tee reactant ‘Hele Cougel eget voy igs Ss vasecky Of Fenokenel gps oy typ Cock eles ame Cineffected. LIMST AT) , * co 0 a, Sn, bm TOP ey oa 5 7) Gy RacerniC mitre cg \ + Ak ecctat hoving Chetal comes Agcemication fares Place che te Presente e& boge . a a Shag f Sd0K1-CoupLind’ ¢ Slord sq)pexhorien BLE oe $d R-R Case, eea® Ply FERS aie hts x Ee 1g ae } fm * oa oe wer ES, a on o Re a eae La, we “orf Sturge im IAHR , Bye Remove, on eos kre an ah Rated Folate Conplra 2 oO a renee as AN An 2~2 hs neces Beh wx \S/ + ORAS ERS sacri ft a RASA x ae Re presence OF amg cE funchon COHy nt. “Go, -C-) i not nf uence eon Reaction, 7 STONES ONE ite tate vane rabacx oF SE ltecoughyge *) . pat ate amet SI rer pa cpt), megs : Dioxane, Licl ote aa cy +74 BySn SY te Aealg a he vnc “Pat aap SONOGHASHIRA = COUPLING ews Ee bering SS SS, ° Rex + cen! Tdtn efenw cud & CuBy 2) cad, SatTS,, SoWwert Reattate a Ueenaf« Ard Allyl X= Belo woh Vs Poy, AY saprbinffb ss yn raza Cae, Gre Es see bey =5 Ean 40 By produc > Good 7.4 yi ca, favente Vo He OF Subskthent en the ate The agde © f fam dervences we praene Cf Any othes Fumttions (-08,-Ntbh Cap, ~esten) eho ~) 1S wot Sukluence Puan, wy Enternal aleyres will not undergo Coupling aeeau t Gy > R-S OR Copper ybate » sqach angen — ——_" ° e Rx ae lat at, c ag lye ~ i fase! curd , oe 7 Z 4 i < \ fy» aye of -Ch, ME Sy pes tesa 7 a pa? cleat CuBr Nant BvctionLe T HARTI ~ Courting [REACTION 2 caf secten. rok aor, a co cata ete ie ee aw Ke U,86,T a ‘or ic) e- ee 2 “nc Fase» Sotaout Monodedate /Neletate phespline Ligands, &) pose died Pre eR OH (or) Aceon cate sbonel (00) wyeomar. = AIRY alongs fy Ally! beagyls Base HGhly puucies, base, nF Bey (teuhue, 1 8 “ss cet 7 FEimecteny by - 960 CW beatles ty,5 Reyl haledes Altasplates and P Co) oF amines, tex). fimeahion af new C0 honing Ho onal Katedes & toublates ond Aad AT Gheads Wie pooene oh fad-CetAlysh aud bac Caled “RAY retd ~Hasikesitay Ouep ting :rate? \~ 4 Hal “isnokjy xed ert ioe Wed C-N bond © Olm|p Subdrtuady Fikig ) Qoring , FE Sparta epee AN Changer oe La” AO oxtdMadat x a“ es qa & » op Je & In PAL Sad pee Ue ad 202 ee ote, “cae *ouon © of PH aX PAU), teu /P ao Bh ez ae (aks 4 ar ek © > pbiias fey NO RS BIWOP nN “Toulenss , afcPy os rd opti, Cu AS ey tenSih eo, , ~ Fier parece EL be * ee p Suk ge yg BBY 5 rf @H-=-R Rx + ek a gen aay & RIX SHC tKyfh, ae : f . pK R-EH tally SOL, Rese Buco he 4 RMD Proc ® Haris eg et pies yp? fr “Ni gy geoy Aor-or'DLEFING -METATHESIS MSTA) EBS ckin metedivesa R= 1 pi-=-—® ae me atkapirtidadier 2 + (mduatynatreced trangfed ob grees Mo dehperet oI Calf cof Heke, retarted, Om) Trans ~alteytatictation. € arate axe > tee PS W Fw * = _—> [o\ Pa ioe ® ® s : 4 F 8 arc pa clebls metathesis Rea wCobtlyets ore qepulas. compose te Me, fa caxel . ote. = & GRves CataLyst + CLEFIN - METATHESIS it~ j Se ——orr > fa * ‘ fa = A, eh a a iy A he an —\n, enrnakon GUE S 1s me geenee noua cy ecto regs <7 LeAi woth Lath =Nph Seong Fed meses, Grugic Codalytt Lb telly, metal betind carbene Cxosh- metadesig Cem) ing cles op metathesis (Rem) merathecis — Rig —eperrg metatheste (Ae™)) Ateeynyh metecthess (AM) Rarely gd ge sae ial Ru- . r ? oT + ll LY’ HREM ame very Cormmnen fel- Bape apne 7 Easy de tun 8 > BH the Ctheg, Genctteng aMecced te Keep pottl net Frgf-lucnce “Acacl om \. .“egy ye yekte > vontous type oF Athte HPreups Or be chaseloged (cyclic, acyelic > Good method “fy prepadatio ef mectiunr SF @ cyettc olefins [a8 menbercd Acbins ete we} 9 baay to henalieg ait the Comore Lo wok Helene by AIR py metSTURE ev WATER WET oe inh¥ Ag, ES Mg & NH ee ee ae ee or yo y ™ wv . . mol NR | De = a 4 ur + Phos a ees + = . IM, eM (Rig Clesing- Metecthest=) '- \ Ps, Sel wy a [8h ( ) f } “FO = “eemGe a mech es Oy te BS PRN WA A sy ” : Teadd” Ay clebing and Catetytt feller by elimination leads de formation of clebfos with cyclastion. <4 Solweat , eco. e 4 : Boul ‘ Zz Grube Pe re nn Ya, Alt vis, \ PaWANNIG) —REACTION 2 Acidic GecuP B. cosbon qeeup Ai am, be Fenised Han G8 bouton ond HY | cated active C78 geen a conten cyeup silelaes te sHidcrassing Op Calleal nadic/achue wa | nesaie sue 3 é 4 Beongh —« agen, Re-coy , EER, w ewrecges Ae-ce Ng-ng_ Ariine méttatahim a ackve = ¢-H fitters using, Pimraldelgcle— aud aafncs \ manne Ren" Compa Kakng dive cmH 4 eto pAnting, Bs tnannich hase Comp Kasiog athe CoH p Hens 4 SUE oF 2H paqnich “att mil —ckord 3 newde A fr By Soh af ay yo af, AS nck Lantos most Gren Pamich bese. A ° chen . K (fae PrALetig a nny a RCE 8 PAL BA " 4 Moric Rak Ly a. & af S& \da© eo - i ph rf saa + HNC ae Gy 2 a i we si OP ate a a 1h Ae 4 ey” My * Enet ~ ° a oe ° EN ae a ~ AK x, p-unsatutatad | mila (nyarrgerrtyee) Cost Beuuyt Cote spd 2 CH o ph + UNS Setondas.y danse muy be “wel Ls co Oo : fipesdine — padeltine Poyreolictone wrbiphalIneos LP acto DARD z . © CSE ans | Hee Heer 0S a = ww | eto aie ® By EHO ain< S hy ors | Oo Poy ete By at, IE By ° ap ves < ins, ened a [a . a « . a cy? x ee OLE adh eas ® Hekesauninepewere Cc bo 5 i fr oo Ace ho ae rm a agg NS ee | 7 BGzenel - y CAH Hey tty A =I . %3 & ti Oo bs Takecah, a Drug (Ana sthelc) 6-28, Sig aunt cs + and tHe O4 ot pe a, cedt pho, + OWE —CQH at ative TIN TRAMOLE COLAA MBN CH Red SS eee = Sy Sees Hed sch ee 8, bs 2-5 pes a 2 | a STORK ENAMINE REACTION STOKE eae a is earners & Aratine clebey are Brainy pe a Er GAs Caen Congas Presfng we, ct femthiong on reach tlh amimer f actdic mekun — Produces Emamting Enontnes F .P-ominey Be dolls thon aaa eramoqer dH omingy @ Durr origmH gut, —t-R + Mit, aes “eo ey = abe R dR | Unstade ancy be + Rent #2 KecHsc-e Ree BR ete gah SOs Lg § Stave “4 = R-sc Kk a cd a hh +*<> = Rod Cycle One? & — & cD eh, g ar \ pester oe + un = R-wm=acR Enamine aw Cow a ew + Rowe — gee Oe eo Raye ak k R R WV Gee 2 . Q ele RK SA Reg = © TRC R Rec =e ange PRE we he ENA MIPERegocetectvity in in, fovenestion th Enarnnes ee i ce : > veh DRY cate as | FO Gla Seg 1 ey (Ly mii PISA 2 PAethonestshonif acid co OF SO H Fy te Case of untytnndatcal Ketone dxentatin of” AB Predent imately at less sushaded st-postion , resulting peda ‘5 map Cor) lees Bubshaded enaetine “S maj * Te> * tp 2 a ap < L Gin IN emer sheric CAcwding Yes ote oF aang’ ound Cig Bene of cleblo Mndesad Desenane io SebiQed veomer “7 of fSmaten lero. Jn Bad tomer free from steric cvawding ty plane orrangurerk OF anima & olefin qrours Pree dele ealtcalion siatilged ener, gh fof feina we ky 7.6 oy ex a ane, t Er “< mt, Seger cad gre, Pa we by PAK Goons + £3 tt _> fomotion cf a-c bonding by Alar tng eledticplultic grees B Enamme , STORK ENAININE — Biy, rs ry, a cy els, Bont Bn we we 2 Be > One of the Ubesk_meticed FEL attepation of 6C ot as,ag et @pycretidine 2 Orel | [re ES Ty “unpaved Keloneg predominately atky” A hess eaeensked Vopestsenop — hy cere, Bonn povanri? © rl? ° & ole Vi | y® fs ON EF ay @ 2 * 5 * buses PERT Ane tey costoy © ws ox ypecalidivne Kg @ af too sr OLY ® wi@Pmuwrelidine Y Sugegreil hat Ou? o. & cristo) 2041 Dey emngs rie clean | seyas tn otr by pte Pal © By" Ls “es ye co Ay AseAISSyrOM RUC Sta Enantfere FPN Aesycomst i = we ees CHRAL of arin 4 eg HS ae Ryd. \rs- 2 waetpfune © sh | 4 OAS be®MICHAEL-ADD TION] REACTION ee Goegugakve adasion of BAive coy fusttion to ackuckes olabin Sh bette medium called michael addition develops neu O-C bonding af Prfesbe of aetvaded lubin, Achvatid clehint Clebin attached ste Eh voit drasking OUP i 4 ANE GH foment pedi Cry Fr queep lertaable ints Cosrtastien ard 98, Cormpeend Activated mith ace oT clabh fase» michael adduct. ( ca ; par cron owes pefebnsk OCF RASES Naot [KOH Nay, KH, REAR as Parine. i Ar “ue I doves ao . Pee ag iahawides BERT S . ~ Keto Cath CN ge deadores age a8 i an fe Hette nitro Res th MhDO eS AK Gndtnt Bue Flousene avichogl Ye » Day h Vovakrsated Cth em ©» e eter ne =* Woe (meting! Hl Keto) QO + + Putte os thc @ «+ ame een re 6 “ + oni to a= | re Kee o sf a 4 ost Nas > Oo : son oR an tuft Cenreamate i fre accep sertnoniieh) Xe a xe — i = , re ee “a mvs Aldi {v" Q e a ent XP for 40k 09 ga, the CASE OF UnSyermetnical Ketones Robin Seales Gannurlabon Da po of Stable ae Lmccht glace ar be Subshtaed ocpesitinns duets tee enc. a © : G- ee Coe © S ee + boy Ne =a (Aldet ) 43 a © ar Best > ats Se DO Rebindon PH clue -fe Bose er MesichiudvanteMES oon, tae! of es eo power vol AES = Jey she (w+ OE Be es ah =, Nal . oe wey mee aaa 4 ti e. a % ob’ + 2) oO ae Ansty LG sk ce me ASS Oe Bet Rue ° Oy 5 wachae) we a eee EeoO yp 2s HNS SP Urecbinrabel el Bbtroteledy at we Lee one ce x Qebcot ) om st- oe ca, 87 Peg » MOE EY Hea cte Rou, + wang antec * St~ tone FACE MANN -LOEFELER- FREYTAG RERCTN | LF-Réastion- ——————— as Ti ® yoo VB ore oot . ; raf J a ha i 5 ok. Sred - Goh Fete 8 Gosertien dy NeHalo ordre havias qa S — aN) ani oe & ceca tune. phair eh MRED Hetewey clee sith use & CEEEE ev-Reamel Condition ig Called HLF Am. Niteteantnes prepasted fem ambass ny treaties NE was> eg RY ane “ aS GN v y yaALY Baa es. at + a * ae » gee oe ot, ' * of C3 +7 13 Nicotine oe ® SS 43 of. aes ho Gas +& us ae Cap feed Ca Prete < é . an ue? -@ , *) AMS . OOS 7 CN a." Lae RU nog - “cots is. Sree OE go ee oy WK —oratopt Png SER Og wy #3 4 > ws ‘Che a ov t or, AY . \ SS fk 3 : ;WITTING Reaction - WRT Reser yl EMNAe OO Cegis 4 poomtles Phesperancs Comvesion f Combenal Conngds Sto Clebins sort phatphdous yltde Go) ec Rhespemons ig Called Atty Aen “ER Boho 7 Denon R Oy ee ing Moe Cy mild seacken Gr Good yer yetlda col} Cosy to prepone nono, dt tetaubsttded ebbing foo the te, of Costin €asy te peaict location of cloudle bond Stagulting Product, Obways nee double bend develops ak Caxbeny Capen. LimtTATION, aneree ( Ree easy Ae Propane -teba Rubelotited chi @ Gxppradact phesphoou oxtdes tn zotuble fin wales... Babbeteat te -. Mabbteultt to Aemove Amn mitre - % Not fosy +o Uelafe olobin tm pede form. & Sterner -sdetvily t olen medion “unpredictable deptnde upery several -facteds. % Nalene oh Solvent , Nabe Ch intterediate rrdtine oh Acackant Nakine of Rr Conditions - Se ' Selves. Day etre eho, pee, THF Tok congitiors Bh tae absence ob oxygen a we ARK sb] ox [He medicc FUME toting not Alpi atdehydes | Ketones -Avematic atdedydes {- Conjagative [* Hebesoty ic "yr Ally he “fa Reagedks p-lptide CAS ples prhaues. (oppite ome adjncont ia cata 1H) ate P+ h Re aly Pony fey Re phanyl very Common. = Dowadieg F sitmdrcouding A Kyl try). Seeley: 2 > C4 7 ED = eit drcunteg, , De Dowating Seavsiity by P-ylsde ctopenda matty on’ nature eb qrape oc Carbanion, % ir Anewng gp Skalbity - Increases KDenaticg 9 easily — deewtate aR PBS, # oF 8g > nee, ® mB R Stowilty dy yisde Conbtmles Stereo Seleckvity %m clebin Pebmaten Unstare. YUde => = —elebin moje Goble yde 5 €-cleben Sere Stove pode => THE ote2. e Be Sims Lob ine PE es Tq vating 9 “yttaees one used. < Bro ee tan seve metigl de ategile (LDH) favouse E-oteb-ae —P Dh other “than b —boter used witty mug are Baw, cy, teiPO these wR ane Le Salt free wrt Axo — Fareuss —t - clebvnt- a Sov \ ts ale Eq, = Gable yiide slew Ren eit Cookery! Compormd, Unstabte” witty yltde fast m Fien ioith “Condbrnyt, Compound! mde Gable yde > Los Heattive Legs lable YORE a made Peachae we “b-FC — +. aa ylide prespehanes. fe Swi “e * “— > Kom) e make stable ylide Logecame “te mde pighly Stable ylHe —aore Ynenk fo eag Pn Highty Cable, nest because of Aromakicily okion ty witlig pongo © eae a ee afin Be «He, Rees ears PY “ Yade Vive] dversn) RCH = Phesity eases Keo PEO Bo i, = Pts © at afer — ft “4 ey Re a as Boy eye othe 4 exis Ofe.-prosprotane. Snscluble tn ches, Fnkermentiase Diffie te we | pe Boring gerd attvacion fdowteg PSO bend. bipreduck-from Sv” wdvore Retain Hhed vet observed ‘a all Vig Meng. Some dt the witig mms dreetly produces exo. -phosphatant witgouk prepara bekone phon eves Getain x dned can pe isolats) from Aun mixture. Pty 4B) “otha omPPhs, ry prey ica atta = R i aor ko | ara ° Bite, 0 o & Hop of a 4 “thane OF too CHiwol Codes In the beloin Can have Stereo Boma , nytt Fs “iyo thee ane ty decompetition tm Acbin depend on nating ch Serge “Bom i ‘ % Betain Suey Cod? oy Syn_Ominent Oeminadiont PrePacd yt hite yo? ~— ff & sno ‘ i ebeRyatioy Ses ; if w ake. a E£-debinan ee es ain yr & & Ercgod Teo ede 3 Cuero steric cxousdg)) 4 ee PrP Em =e ast -F =@ Wea Oe Pog = Some & He Coereoryl Compas nek fn wiltig mn with Simple yltde, due te Nigh steric crowding ak Combenig funthiino +o owercome Bese Crowdine ooion % phosphddanes Cm) dtantorr of P-¥tide ae used. wd opt —,INQD ORTH —Emmon’e BEPCTION SD) YoRNER-EPAMONS oLEFN Ato: e defects WORD Ayo + RP ce SHC fe bare dome debedt fh desto CeBseck tess woRTe) ~trmman's Rat, cleveloea by medt fying totic reagent Senge volifie eageut Phesphdione - meds fiedisfarte weogente plrsrhoncdles iy Ley, anctes (8 ahed é.C Comexttd Tnls elebins hy Laing preston TABRDWORTH -HoRHER EMON 'S AY that me. ae te 2 Bult Prva dango / 7 Oby products one easily Soluble wr teal. ot Easy te Pemove fy +B ae mike, @® E- Selective Prem @ Grow tere Subetituted elebiyg ake Can be preepascd piaipoATEs pREpoRATEN : : . est bi ve = caf “, Aveyt grespistes | a gy a eof hae BY) wae ae Qen\ corvesion) - ty CR \ © s Q WR ae] pr ~ | to ws / a ° 48S & AME . 08kz S ge we 4 ‘y? + exer Y= CAR —> cH — COR * 8 § e aeche Gai Glee Pessie 6 {err Oost 3 elke RL SA eo RCH ~ oR eR E pen Oh : he pao © % onthe R < Nese + ao cue Aeeiby, Seluble iy wader. whe focy -b Aemeve . ® 0 Th So Yo SPacatge yy Lo ohye=d * a Teas i" cof Trams, (058). Seg Clonamete ; adomele cular toad nse Emm ants mr x wm (Wet Ake |©. Phe eeu, —. Fh, Oey. + HCHO “(thy =o + OCH) pene Rac Can tundesgo agenalysie. STOR BE - CONDENSATION > (Diy! Succinate) ae Se e- . 8 8h fase A Neo + se > R § chcctiog! Sucemate 4 6-6 one ef tre Estey gets hydrelysed. Condensckin Hho Sn the presen base Calle, MArbke Condenser mech & ors ee Nest id a rose al 5 je } Be © Rh + sr hase , — fhese ce ® © ftDIE CKMON'S ~ CHCLUZaT ION ‘= ; eutite iy Dickman cucliprshin Broaertieaas, eOtgation of dieser tse 8 2 COs oe ra BBQ G : ca eyclonattorn ond Fg @¢S Aloalkarne . Foetal succinate : Ker ost, Aros LN “ask CO , MES she ° we xe, € ar Tesh adh 2 este a yee Bose 5 ° oe eo ABs 7a ee er / a = « M oy { -8-“ee I = it Base Cotalyseel 5 Combanien WErnBiale, pew e—¢ bentag Rie relocates wrote PALE prem oF Cytloatkanene & cy cloalkangs , CHICHHBARYN REACTION e- ~Prmetnoction of Nitragen Hetascycline > co a Higcreuup - t ZN Rechte ~ S Rant, ye HO a RH) na xv Bis ew he, 5 2 ORD > Lig ty arr. te eg Ook. = cra, 7 a mentee be Ret BoquinclineGQ Ce B te Panties OS TL ns mntrdine eer tig!