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Biopharm PRV Yr PPR 2024

The document outlines the examination structure for the Biopharmaceutics and Pharmacokinetics course, including multiple-choice questions and short answer sections. It covers key concepts such as drug dissolution, pharmacokinetics parameters, and various drug transport mechanisms. Students are required to illustrate answers with sketches and all questions are compulsory.

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Saivi Sharma
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10 views4 pages

Biopharm PRV Yr PPR 2024

The document outlines the examination structure for the Biopharmaceutics and Pharmacokinetics course, including multiple-choice questions and short answer sections. It covers key concepts such as drug dissolution, pharmacokinetics parameters, and various drug transport mechanisms. Students are required to illustrate answers with sketches and all questions are compulsory.

Uploaded by

Saivi Sharma
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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B.Pharm.

CBCS Pattern Semester-VI


BP604T - Biopharmaceutics and Pharmacokinetics

P. Pages : 3 GUG/S/24/14140
*0592*
Time : Three Hours Max. Marks : 75
_____________________________________________________________________
Notes : 1. Illustrate your answers wherever necessary with the help of neat sketches.
2. All questions are compulsory.

1. Multiple Choice Questions. 20x1


1) The equation that describes rate of drug dissolution from a tablet is known as =20
a) Ficks law b) Noyes Witney equation
c) Henderson Hassel belch d) Stokes law

2) The manner in which the drug should be taken is


a) Dose b) Dosage form
c) Dosage regimen d) None of the above

3) The distribution of drugs into central nervous system usually depends on


a) Aqueous diffusion b) Facilitated transport
c) Lipid diffusion d) Active transport

4) Some Vd values are give below. Which Vd indicates very high plasma protein
binding of drug
a) 7 L b) 102 L
c) 420 L d) 230 L

5) The RBC components which can bind to drugs


a) Haemoglobin b) Cell membrane
c) Carbonic anhydrase d) All of the above

6) System of enzymes in liver responsible for oxidative biotransformation


a) Microsomal enzymes b) Non microsomal enzymes
c) Both a and b d) None of these

7) Renal clearance is expressed as


a) Rate of urinary excretion / plasma drug concentration
b) Elimination rate / plasma drug concentration
c) Rate of urinary excretion / elimination rate
d) Plasma drug concentration / Rate of urinary excretion

8) The characteristic of non-linear pharmacokinetics includes


a) Area under curve is proportional to the dose
b) Elimination half-life remains constant
c) Area under curve is not proportional to the dose
d) Amount of drug excreted through remains constant

9) Causes of nonlinearity in biotransformation includes except


a) Saturable metabolism
b) Enzyme induction
c) Saturable plasma protein binding
d) Metabolite inhibition
GUG/S/24/14140 1 P.T.O
10) USP apparatus 5 is
a) Flow through cell b) Paddle over disk
c) Cylinder d) Reciprocating disk

11) AUC gives the measure of


a) Extent of absorption b) Rate of absorption
c) Amount of drug d) Both a and b

12) The average amount of time spent by the drug in the body before being eliminated
is called as
a) AUC b) AUMC
c) MRT d) MDT

13) The formula to calculate steady state concentration follows IV infusion


a) Css = infusion rate X Clearance
b) Css = infusion rate / Clearance
c) Css = infusion rate - Clearance
d) Css = Clearance / infusion rate

14) Time to achieve steady state drug levels in influenced by


a) Dosing interval b) Loading dose
c) Dose size d) Number of doses

15) In one compartment open model, the term open indicates input and output is -----
a) Unidirectional b) Bidirectional
c) Non-directional d) None of the above

16) The primary pharmacokinetics parameter clearance can be calculated by ----


a) Cl = KV b) Cl = Dose / AUC
c) Cl = (DA / dt) / C d) All of above

17) Drugs having ---------- half-lives take a very short time to achieve plateau
concentration.
a) Shorter b) Longer
c) Intermediate d) None of the above

18) What is the molecular weight cut off for biliary excretion?
a) Less than 300 Dalton b) More than 300 Dalton
c) Less than 200 Dalton d) More than 200 Dalton

19) Elimination half-life of a drug is 3 hours. What would be the elimination rate
constant value for first order kinetics.
a) 0.135 per hour b) 0.314 per hour
c) 0.231 per hour d) 0.202 per hour

20) Absorption rate constant can be calculated by the


a) Sigma-minus method b) Method of residuals
c) Wagner-nelson method d) Both b and c methods

GUG/S/24/14140 2
2. Solve any two. 10x2
=20
a) Discuss various mechanisms of drug transport.

b) Define Bioavailability and explain different methods of measurement of


bioavailability.

c) Explain different types of Pharmacokinetic model in detail.

3. Solve any seven. 5x7


=35
a) Write a short note on pH partition hypothesis.

b) Explain methods to determine K m and Vmax graphically?

c) Discuss in short, the physiological barriers to distribution of drugs.

d) Write a note on types of compartment models.

e) Give a note on loading and maintenance dose and give various formulae to
calculate loading and maintenance dose.

f) Explain about the Renal excretion

g) Write about Phase - I reactions

h) Write short note on sigma minus method.

i) Write short note on plasma concentration time curve.

*************

GUG/S/24/14140 3 P.T.O
GUG/S/24/14140 4

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