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Conductivity Method

The conductivity method, utilizing a Coulter counter, measures particle sizes from 0.5 to 500 um by assessing particle volume and converting it into diameter. This quick and accurate technique is used in various applications including studying particle growth, drug dissolution, and the effects of antibacterial agents. Despite its high cost, it can analyze approximately 4000 particles per second, providing efficient size distribution results.

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26 views2 pages

Conductivity Method

The conductivity method, utilizing a Coulter counter, measures particle sizes from 0.5 to 500 um by assessing particle volume and converting it into diameter. This quick and accurate technique is used in various applications including studying particle growth, drug dissolution, and the effects of antibacterial agents. Despite its high cost, it can analyze approximately 4000 particles per second, providing efficient size distribution results.

Uploaded by

aakashxbrvgr
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Cpnductivity Method

W'article size ranging from 0.5 to 500 um is measured by conductivity


method. This method gives number distribution. In fact, particle
volume is measured and converted into particle diameter. Coulter
counter is used to measure the particle volume. Thus, in this method,
Size is expressed as volume diameter, d, which describes the diameter of
the sphere having the same volume as that of the asymmetric particle
This is a quick and accurate method, but the instrument is expensive.
This method finds applications in the study of
(a) particle growth in suspensions and solutions,
(b) dissolution of drugs in a desired medium, and
(c) effect of antibacterial agents on the growth of micro
organisms.

(Principle : Working principle of the Coulter counter may be ex


plained with the help of Figure 6-9. Particles are suspended in a
conducting electrolyte (say sodium chloride). This dispersion is filled in
the sample cell, that has an orifice and maintains contact with the
external medium. Electrodes are placed in the solution (inside the cell)
and suspension (outside) as shown in Figure -9. A constant voltage is
applied across the two electrodes. In this position current passes. When
a suspended particle travels through the orifice, it displaces its own
volume of electrolyte into the beaker. The net result is a change in
electrical resistance. This change in electric resistance is termed as
voltage pulse, which is related to the particle volume. This voltage
pulse is amplified and fed to a pulse height analyzer. This analyzer is
previously calibrated in terms of particle size for different threshold
settings.
(ho ICKOMERIICS 205
amplifier
Pulse volume.
particle
Threshold
circuit
determine
amplifier to
Main to particle
volume
proportional
Pulse
height used
solution
and
Electrolyte
particles counter
Coulter
Electrolyte
o
of
diagram
+ counter
switch
solution Schematic
Orifice
6-9.
Figure
Mercury
For a given threshold value, the pulses are electronically counted.
By changing the threshold settings gradually, number of particles of
can be
each size range is obtained. Thus the particle size distribution
obtained.
Condáctivity method is also known as stream scanning, i.e., a fluid
suspension of particles passes through a sensing zone, in which indi
vidual particles are electronically sized, counted and tabulated.
Advantages : Using Coulter counter apparatus, approximately 4000
analysis
particles per second can be counted. Therefore size distribution
can be completed in a relatively short period of time. It gives reason
ably accurate results.

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