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All Reaction Applications

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All Reaction Applications

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ORGANIC CHEMISTRY ASSIGNMENT

APPLIC ATION OF
REACTIONS

BY : NABEEL AHMAD
ROLL NO: 48
GRIGNARD REACTION
1. Grignard reagent plays an important role in organic
chemistry due to its ability to participate in reactions that
lead to the formation of new carbon-carbon bonds.
2. It is used to determine the number of halogen atoms
present in the halogen compound.
3. It is also used to manufacture chemo-catalysts, amides,
acetals, amino compounds, organosulfur compounds,
ethers, ketones, aldehydes, etc. These are used for the
production of several compounds having important
applications in pharmaceuticals, perfumes, and other
excellent or specialty chemicals. (Source:
https://protonstalk.com/chemistry/grignard-reagent/)
CANNIZARO
REACTION
1. The Cannizzaro reaction is an essential synthetic route for
preparing both carboxylic acids and alcohols from
aldehydes.
2. The reaction is widely used in organic synthesis and is
particularly useful for converting aldehydes that are
difficult to oxidize by other means.
HOFFMANNS REACTION
1) It is used to produce primary aromatic and aliphatic
amines.
2) It is used in the preparation of aniline.
3) It is used in the preparation of anthranilic acid and
phthalimide.
4) Hoffmann reaction does not change the symmetrical
structure of -phenyl propanamide.
WOLF REARRANGEMENT
 The main applications of the Wolff rearrangement in organic
synthesis are the homologation of carboxylic acids (Arndt-
Eistert reaction).
 It is also used in situ production of ketenes and α-oxo-
ketenes as reactive intermediates.
BECKMANN REACTION

 It is used in the industries for the synthesis of paracetamol. This


integration is achieved by the process of conversion of a ketone to
a ketoxime with the help of hydroxylamine.
 The Beckmann Rearrangement synthesis is helpful in the
production of some chloro bicyclic lactams.
WOLF KISCHNER REACTION
 The Wolf-Kishner reduction has been widely utilized to
convert carbonyl groups to methylene (CH 2) groups.
 Synthesis of pyrroles
 Reduction of camphor to comphane
BAYER VILIGER
a) The main application of the Baeyer villiger oxidation
reaction is the preparation of ester or carboxylic acid from
ketones or aldehyde.
b) The reaction is employed to convert cyclic ketones into
lactones. Lactones are important building blocks in the
synthesis of natural product.
PERKIN REACTION
Applications of the Perkin reaction include 23:
Making cinnamic acids, which are carboxylic acids that occur
naturally.
Making α-, and β-unsaturated aromatic acids which are
generally used in the pharmaceutical sector.
Synthesizing phytoestrogenic stilbene Resveratrol.
Production of several commercially important compounds.
MANNICH REACTION
The Mannich reaction is used in many areas of organic
chemistry, Examples include:
alkyl amines
peptides, nucleotides, antibiotics, and alkaloids (e.g. tropinone
[11]
)
agrochemicals, such as plant growth regulators [12]
polymers
catalysts
FRIEDAL CRAFT REACTION
Applications of Friedel Craft's Acylation Reaction
It is also employed in the Haworth reactions.
It is employed in the synthesis of aromatic compounds with
functional groups such as aldehydes and ketones.
One of the most prominent applications of this reaction is in
the manufacturing of dyes, such as xanthene dyes
PINACOLE PINACOLONE
The applications or uses of the pinacolone item created from
the pinacol pinacolone rearrangement include:
Pinacolone is utilized in Pesticides, Fungicides, and Herbicides.
It is utilized to set up the cyanoguanidine drug – pinacidil.
Another medication utilization of Pinacolone is its utilization in
Stiripentol, which is utilized to treat epilepsy.
Pinacolone is utilized to create triadimefon which is utilized to
control contagious sicknesses in horticulture.
WAGNER MEERWEIN
The Wagner-Meerwein
rearrangement has several key applications in organic che
mistry
123
. These include:
Widely
used in the synthesis of a variety of natural products and dr
ugs
1
.
Used in the synthesis of other heterocyclic compounds 1.
Preparation of polymers1.
.
DIELS ALDER
Diels Alder Reaction is very important reaction in organic
chemistry and has many applications like:
Natural materials synthesis like plastics and rubber and plastic
is one of the most important applications of Diels Alder
Reaction
In pharmaceuticals and steroids synthesis (ex: cortisone and
Vitamin D).
WITTING REARRANGEMENT
There are several uses of the Wittig reaction, and some of
them are as follows:
It is known to produce alkenes from carbonyls and phosphorus
ylides.
It has wide applications in the field of medicine and
pharmaceutical production.
It is also used in the synthesis of alkaloids.
This reaction is also employed in the industrial production of
vitamin A.
ARNDT EISTERT
o It is used to make longer carbon chains.It takes starting
molecule called carbocylic acid and adds one more carbon to
it resulting in longer carboxylic acid.
o Natural substances found in plants or animals often have
long carbon chains. This reaction helps the chemists to
make these natural substances in the lab by extending.
o The reaction is used to synthesize special chemical that
have specific properties. By extending carbon chains,
chemical can create desired for various applications.
FAVORSKII REARRANGEMENT
 Some of the applications of favorskii rearrangement
reactions are:
 This reaction can be used to prepare bicyclic esters.
 Steroid and nonsteroid can be prepared by using this
reaction.
 Pyrollidine can be prepared using this reaction.
METAL HYDRIDE REDUCTION
i. Application of Metal hydride reduction reaction
ii. Preparation of unsaturated alcohol from unsaturated
carbonyl compounds
iii. Reduction of ester to alcohol
iv. Reduction of carboxylic acid to alcohol

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