BAx00 Analyzers

New generation with LED Technology

Why should a medium workload

lab user have a BA400?

Ignasi Roig
Ignasi Roig
Product Manager
Product Manager
November 2020
November 2020
Contents
Contents

• What about BioSystems?

• Experience and evolution
• General Characteristics
• Main components
• Technology
• Marketing
 What
Whatabout
aboutBioSystems?
BioSystems?

16 subsidiaries and representative

offices distributed around the world
 What
Whatabout
aboutBioSystems?
BioSystems?

We offers complete systems

 Experience
Experienceand
andevolution
evolution

Long
Longexperience
experiencein
inRandom
RandomAccess
Accessanalyzers
analyzers

A15 (150 t/h): BTS350: the first

A15 (150
Perfect t/h):
target BTS350:with
photometer the first
LEDs
Perfect target photometer with LEDs

A25 (240 t/h): the A25V2 (240 t/h):

A25 (240
first of itst/h):
kindthe A25V2
Cooling(240 t/h):
zone
first of its kind Cooling zone
for reagents
for reagents
 Experience
Experienceand
andevolution
evolution

Long
Longexperience
experiencein
inRandom
RandomAccess
Accessanalyzers
analyzers

BA200 (300 t/h):

BA200 (300 t/h):
Benchtop
Benchtop
analyzer
analyzer

BAx00: Dedication time on improving

BAx00: Dedication
our systems (HW,time
FW on
andimproving
SW)
our systems (HW, FW and SW)

BTSxxx:
ReadyBTSxxx:
for new
Ready for new
launches
launches
BA400 (560 t/h): A15 Cooling:
BA400
New (560 t/h):
generation of A15refrigerated
Adding Cooling:
New generation
analyzers of Adding refrigerated
reagents
analyzers reagents
 Experience
Experienceand
andevolution
evolution
BA400

BA200

Current BioSystems Analyzers

BTS350 A25V2

A15
A15C
 Experience
Experienceand
andevolution
evolution

 Pre-definition for a new BA analyzers:

Our understanding of a good design:

• Functionality
• Reliability
• Low cost
• Easy maintenance
• Automation and Connectivity
• Aesthetically attractive
• Easy manufacture
 Experience
Experienceand
andevolution
evolution

Basic specifications for a BA analyzers:

• High capacity for refrigerated reagents and samples
• Barcode readers
• Continuous Sample Loading
• Long autonomy of operation
• Components of high durability
• Low water and electric power consumption
• Washing station to evaluate the status of each cuvette
• Friendly software and intuitive interface
• ISE module (optional) – including Lithium
• Flexible connections to LIS (ASTM, HL7)
All these features and more have been
incorporated in our BA400 system
10
BA400
BA400General
GeneralCharacteristics
Characteristics
BA400
BA400General
GeneralCharacteristics
Characteristics

• Optical system based on LED technology

• Maximum throughput of 560 t/h

integrating Photometry and Potentiometry
(Na⁺, K⁺, Cl⁻, Li⁺)

• ISE module optional (electrolytes)

• It can be installed a posteriori (Li⁺ is

another optional fourth electrode)

• BA400 is directly linked to our own

dedicated reagent line BA
BA400
BA400General
GeneralCharacteristics
Characteristics

• Reading time (reaction) up to 10’21 min

• User autonomy up to 9 hours

• Easy access to waste and washing

solution containers

• Automatically emptying of the internal

low contamination waste container

• Automatic filling of the internal distilled

water container

• Compact system without external

components (not peripherals)
 BA400
BA400General
GeneralCharacteristics
Characteristics
Reaction
ReactionRotor
Rotor
Mixers
Mixers
Reagents
ReagentsProbe
Probe

Reagent
ReagentTray
Tray
Washing
WashingStation
Station
Sample
SampleProbe
Probe

Sample
SampleTray
Tray

ISE
ISE
 BA400
BA400Working
Workingcycles
cycles

The analyzer cycle time is 9 sec (400 t/h):

Name Cycle Time (sec) Description
R1 1 9 R1 Dispensation

’ 30’’
ºC 2-30 18-270
0
Termostatized
= 1
S 31 279 Sample c
se Dispensation
3 0
ST1 32 288
t im e: 6 Stirrer1: Sample + R1
on
L1 32-65
e act i
288-585
r Reading
R2 66imum 594 R2 Dispensation (only bireagent test)
ST2 M ax
67 603 Stirrer2: Sample + R1 + R2
L2 67-100 603-900 Reading
WS1 101 909 Starting in Washing Station
WS2 111 999 Starting Drying Cycles
 BA400
BA400Working
Workingcycles
cycles

Example in Bilirubin Total DPD:

Cycles of Reading / Reaction (Software): Bireagent Differential
The reaction starts after adding the sample

Name Cycle Time (sec) Description

S 1 0 Sample Dispensation
ST1 2 9 Stirrer1: Sample + R1
L1 4-36 36-324 Reading
R2 36 324 R2 Dispensation (only bireagent test)
ST2 36 324 Stirrer2: Sample +R1 + R2
L2 36-70 324-630 Reading
BA400
BA400Sample
SampleRotor
Rotor

• Capacity up to 135 positions for samples

• 90 with barcodes + 45 additional

(calibrators, controls or samples)

• Non fixed positions neither samples,

controls, calibrators nor STAT

• Primary tube and pediatric cups

• Automatic dilutions of high concentration

sample and calibrators

• Pre-dilution and Post-dilution up to 1:200

 BA200/BA400
BA200/BA400Reagents
ReagentsRotor
Rotor

• Capacity for 88 refrigerated reagents bottles

• Dedicated bottle specially designed: 44 bottles of 20mL + 44 bottles of 20mL or

60mL

• Temperature range from 6º to 11º C by peltiers (up to 21ºC room temperature)

• Barcode detector on board (automatic monitoring of reagents identification and

volume)
 BA400
BA400Sample
Sampleand
andreagents
reagentsarms
arms

•3 independent probes for sample and reagents (S + R1 + R2) + 2 mixers

•Reagents probes pre-heating

•Internal and external probe washing

•Liquid level detection and vertical collision protection

•Clot detection for samples

BA200/BA400
BA200/BA400Reaction
ReactionRotor
Rotor

• High quality reusable methacrylate

rotor

• 120 wells termostatized to 37ºC

with peltiers

• Dry incubation – not consumables

• Reaction volume 180-600 µL

(BA400)
R1: 90-450 µL; R2: 10-300 µL
Sample: 2-40 µL
BA400
BA400Ceramic
Ceramicpistons
pistons

• Ceramic piston pump with low

maintenance

• High durability of components:

8 millions of cycles (5 years)

• Diameter of pistons:
– Sample: 3 mm
– Reagent: 8 mm

• Pipetting resolution:
– Sample: 0.1 µL
– Reagent: 1 µL
BA200/BA400
BA200/BA400Cuvette
Cuvettewashing
washingsystem
system

• Washing station with 8 needles:

– Aspiration, Washing, Rinsing, Drying

• Rinse water is thermostated (40ºC)

• Automatic rejection of damaged cuvettes

• Low consumption of water:

– Less than 14 L/h

• Overflow detector

20
 BA200/BA400
BA200/BA400Cuvette
Cuvettewashing
washingsystem
system
Detection overflow rod

Automatic rejection
of damaged cuvettes

ASP. High Conc. waste

DISP: Washing solution

ASP. Low Conc. waste

DISP: Washing solution

ASP. Low Conc. waste

DISP: Distilled Water
Dryer
ASP .DW (LCW) ASP. Low Conc. waste
DISP: - Check cuvette DISP: DW
BA200
BA200General
GeneralCharacteristics
Characteristics

Throughput : Clinical Chemistry and Turbidimetry 200 test/h

Ion Selective Electrode 320 test/h
 BA200
BA200General
GeneralCharacteristics
Characteristics

• Benchtop Clinical Chemistry analyzer

• Cycle time of 18 sec (200 t/h)

• Real throughput of 200 t/h independently

of mono or bireagent reactions

• 300 t/h as a maximum throughput

including ISE module (Na⁺, K⁺, Cl⁻, Li⁺)

• User autonomy up to 7 hours (continuous

working)

• High flexibility in the reagent and sample

capacity (88 positions)
 BA200
BA200General
GeneralCharacteristics
Characteristics

Features shared with the BA400:

•Same Spare Parts

•Same consumables and accessories

•Same barcoded reagent containers

•ISE module optional (electrolytes)

•Compact system without external

elements

•Low maintenance
 BA200
BA200Working
Workingcycles
cycles

The analyzer cycle time is 18 sec (200 t/h)

Name Cycle Time (sec) Description
R1+S 1 18 R1 Dispensation
’ 30’’
= 1 0
Stirrer 1 18
ec
Stirrer1: Sample
0 s
+ R1
L1 2-17 32-306
e : 63
Reading

i on ti m
R2 18 324
c t Sample Dispensation
ST2 18 m
u324re a Stirrer2: Sample + R1 + R2
i m
ax 342-630
L2 M
19-35 Reading
WS1 36 648 Starting in Washing Station
WS2 46 828 Starting Drying Cycles
 BA200
BA200Sample
Sample//Reagent
ReagentRotor
Rotor

• High loading capacity and flexibility for sample and reagent positioning with free
distribution

• Reagent position can be converted to a sample tube or pediatric position

BA200/BA400
BA200/BA400Optical
OpticalSystem
System
BA200/BA400
BA200/BA400Optical
OpticalSystem
System
 BA200/BA400
BA200/BA400Optical
OpticalSystem
System

• Detector: Main photodiode + reference

Reaction
Reactioncell
cell photodiode (light measured before and
after crossing the reaction cell)

• Optical compact system formed by 8

monochromatic LEDs

• Wavelengths: 340, 405, 505, 535, 560,

600, 635 and 670nm

• Light source with barely unlimited life,

LEDs (more than 50,000 hours)
LEDs
• We use the cuvette blank in each
Main
Mainphotodiode
photodiode reading to calculate the concentration
Reference
Referencephotodiode
photodiode
Stable read with a resolution of 0.0001 Abs
(Stabilize any drift of the light source)
 BA200/BA400
BA200/BA400Software
SoftwareFunctions
Functions
Strengths:
Strengths:
Based
Basedon
onthe
thefriendly
friendlymode
modeofofprevious
previousanalyzers
analyzers(A15
(A15and
andA25):
A25):
improving
improvingevery
everyyear
yearwith
withinput
inputfrom
fromend
endusers
users
 Reaction
Reactiongraphics
graphicsininreal
realtime
time(abs/sec)
(abs/sec)
 Reactions
Reactionsofofdifferent
differentreplicates
replicatesininthethesame
samegraphic
graphic
 Automatic
Automaticpredilutions
predilutionsandandpostdilution
postdilution
 Panic
Panicranges
rangesand anddynamic
dynamicreference
referencerange
rangebybyage
ageand
andgender
gender
 Customable
Customablemodule
modulefor forCalculated
CalculatedTest Test
 Possibility
Possibility of adding “off-system” testsresults
of adding “off-system” tests results
 Automatic
Automaticmonitoring
monitoringofofreagents
reagentsidentification
identificationand
andvolume
volumeininreal
realtime
time
 Cross
Crosscontamination
contaminationamongamongteststests(needle)
(needle)and
andinincuvette
cuvettewells
wells
 Complete
Completeand andcomfortable
comfortableQC QCmodule
modulewithwithWestgard
WestgardRules
Rulesand
andYouden
Youdengraphs
graphs
 Management
Managementand andautomatic
automaticmaintenance
maintenance
 ……
 BA200/BA400
BA200/BA400Software
SoftwareFunctions
Functions
Monitor Screen
Monitor Screen Test selection
Work session preparation Test selection
Work session preparation

Sample positioning
Sample positioning

Alarms Screen
Alarms Screen
p an
k e e l i ty
n u o
t t io n a
s me f un c
at i o n ac h
p r
e p of e
t e o - u
Working Session Screen
Working Session Screen
ISE Module Screen
ISE Module Screen
m p le Reaction
l l o wRotor
o
C imal f oReaction Rotor
Reagent Rotor
Reagent Rotor

op t

30
 Options
Optionsand
andRequirements
Requirements
 INSTALLATION
• ISE module
• Uninterruptible Power Supply (UPS)
• PC is not included (provided by the distributor)
• Water purification module (provided by the distributor)
• Connection to the LIS (support from BioSystems)

 CONSUMABLES
• Rotors (10 units), code 11485
• Concentrated washing solution 500mL, code AC16434
• Acid washing solution (WS1) 4x20mL, code AC17201
• Alkaline washing solution (WS2) 4x15mL, code AC17205
• Sample wells (Pediatric cups) (1000 units), code AC10770
---------------------------------------------
• Reagent pack for ISE Module
• Electrodes (Na⁺, K⁺, Cl⁻, Li⁺, Reference)
• ISE - Cleaning Solution
• ISE - Urine diluent
• Water purification cartridges (provided by the distributor)
 Options
Optionsand
andRequirements
Requirements
Environment: 10ºC to 35ºC ( 30ºC in case of ISE)
HR: <85% without condensation.

1500VA

Uninterruptible Power Supply

500VA

Water Type II

•CPU Equivalent to Intel Core i3 Main (Distilled

@3.10 GHz or higher water supply)
•Operating system Windows 10 (64 bits)
•RAM 4Gb
•Hard disk ≥ 40Gb
•CD-ROM/DVD Yes
•Monitor minimum resolution 1024 x 768
•Connector of serial channel USB
Tank (Distilled water
supply module)
 System
Systemconcept
concept

 The BA presentation uses a specific design of bottles and a specific

barcodes. It is the only option that fits in BA400

 Two possible presentations are offered for each test

 The BA presentation is perfectly suitable for use in other analyzers in

the market (Olympus, ADVIA, DIRUI, Hitachi917)

 Wide range of portfolio including esoteric test (special biochemistry)

 System
Systemconcept
concept

 BAx00 platform is a complete system by integrating dedicated

reagents and analyzers under the same brand

 BioSystems is a company that focuses on offering complete solutions

(reagents & instruments) jointly validated. This situation is different
than our main competitors

 BA400 and the specific dedicated line of reagent BA consolidates the

presence of Biosystems in larger laboratories
 Marketing
Marketing

 MAIN TARGET (general definition):

• BA200: from 40 to 80 samples per day

• BA400: from 60 to 150 samples per day

• Large labs as backup instrument

• Special Biochemistry

• Available for new market opportunities…

 Marketing
Marketing

High
MARKET
MARKETSEGMENTATION:
SEGMENTATION: Capacity
Diversification
Diversificationofofsales
salesby
by Automated
size of laboratory
size of laboratory Segment
200 Patients/day

2000 Tests

60 Patients/day

480 Tests

20 Patients/day

BTS
BTS350
350
180 Tests
 Marketing
Marketing

OUR STRONG POINTS IN THE MARKET:

•European company: manufacturer of our own reagents and

analyzers

•LEDs: Incorporation of an innovative and patented optical

system

•Dedicated reagent: specific line of reagent BA jointly verified

with the most strict FDA protocols
 Marketing
Marketing
BA installations have been distributed all over the world

*October 2020
Marketing
Marketing
 Biosystems designs and develops efficient systems
that implement the latest and best technical solutions

• Smart System
 BioSystems SA as a European Manufacturer of its own reagents and
analyzers, ensure proper functionality of all components under strict
quality and safety standards
We improve the well-being of
people around the world

¡Thank
you ! •www.biosystems.es/new/BA400/ad/en