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Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation management, with a chemical formula of C13H18O2. Developed in the 1960s, it became the first over-the-counter NSAID in 1983 and is commonly used for conditions like rheumatoid arthritis. However, it has potential side effects, contraindications, and drug interactions that should be considered when prescribing or using it.

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6 views14 pages

Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation management, with a chemical formula of C13H18O2. Developed in the 1960s, it became the first over-the-counter NSAID in 1983 and is commonly used for conditions like rheumatoid arthritis. However, it has potential side effects, contraindications, and drug interactions that should be considered when prescribing or using it.

Uploaded by

ali.hassan.pharm249
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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IBUPROFEN

Definition of Ibuprofen
• Ibuprofen is a treaditional non-steroidal anti-inflammatory
drug (NSAID ) and non-selective COX inhibitor used for
its analgesic, antipyretic and anti-inflammatory effects

• The formula of ibuprofen is


2-(4-isobutylphenyl) propionic acid
C13 H18O 2
History of Ibuprofen
• The initial development of Ibuprofen was in 1960
while researching for a safer alternative for aspirin.

• Ibuprofen was finally patented in 1961 and was the


first launched against Rheumatoid arthritis in 1969 ,
with an over-the-counter (OTC) version available in 1983

• Ibuprofen was the first available (OTC) NSAIDs


Uses of Ibuprofen
• Relieve minor pain and inflammation
including Fever, Headache, Muscular aches,
Toothache and Backache

• Used for the Long-term treatment of Rheumatoid


arthritis, Spondylitis and other Chronic conditions
Mechanism of Ibuprofen
• Ibuprofen is non-selective inhibitor of cyclooxygenase
enzyme COX , which converts Archidonic acid to
prostaglandin (PGH2) mediators of pain and fever ,
and to thromboxane A2 which stimulates platelet
aggregation leading to blood clotting

• The analgesic, antipyretic and anti-inflammatory


effects of ibuprofen occurs as a result of decreased
prostaglandin synthesis
Mechanism of Ibuprofen
• Ibuprofen inhibits the activity of both COX-1 and COX-2

• The inhibition of COX-2 activity decreases the


synthesis of prostaglandins involved in mediating
inflammation, pain, fever, and swelling

while the inhibition of COX-1 is thought to cause


some of the side effects of ibuprofen including
GI ulceration.25
Doses of Ibuprofen
• Usual Adults oral dose for mild-moderate pain
200-400 mg orally every 4-6 hours as needed

• Under medical description the maximum amount for


adults is 800 mg per dose or 3200 mg per day based
on an individual response and tolerance

• over the counter (OTC) prescription of Ibuprofen are


labelled to advise a maximum daily dose of 1200 mg
Adverce Effects of Ibuprofen
• Ibuprofen have many side effects including :
● Headache
● Nausea
● Diarrhea
● Constipation
● Dizziness
● Bleeding
● Dyspepsia
● Hypertension
Adverce Effects of Ibuprofen
• Ibuprofen have the lowest incidence of
digestive adverse effect reaction of all the
non-selective NSAIDs

• Regular use of Ibuprofen may eventually cause:


• anaemia due to bleeding in the stomach.
• kidney and liver damage
• increased risk of heart attack.
Drug Interactions of Ibuprofen
• ACE-Inhibitors
NSAIDs may diminish the Anti-hypertension effect of
ACE-inhibitors

• Aspirin
Administration of Ibuprofen and Aspirin is not
generally recommended because of the potential for
Increased Adverse effects .
Ibuprofen antagonistic effect on aspirin
antiplatelet action
Drug Interactions of Ibuprofen
• Diuretics
Ibuprofen can reduce the natriuretic effect of Furosemide
and Thiazides in some patients, the patient should be
observed closely for sings of Renal Failure as well as
to assure diuretics efficacy
• Warfarin-type anticoagulants
used of both drugs together have a risk of serious
bleeding higher than used of either drug alone
Contraindication of Ibuprofen
• Ibuprofen tablets are contraindicated in patients with
know hypersensitivity to Ibuprofen including :
● Asthma
● Hypertension patients
● Heart Attack
● Stomach or Intestinal Ulcer
● Liver problems and blood clotting Disorder
● Bleeding of the stomach or Intestinal
● kidney disease
● Pregnant in 3rd trimester
References
• Zawada ET Jr: Renal consequences of nonsteroidal antiinflammatory drugs. Postgrad
Med. 1982 May;71(5):223-30.

• Adams SS: The propionic acids: a personal perspective. J Clin Pharmacol. 1992
Apr;32(4):317-23.

• Rainsford KD: Discovery, mechanisms of action and safety of ibuprofen. Int J Clin Pract
Suppl. 2003 Apr;(135):3-8.

• Bergner T, Przybilla B: Photosensitization caused by ibuprofen. J Am Acad Dermatol.


1992 Jan;26(1):114-6
• Parameter on chronic periodontitis with slight to moderate loss of periodontal support.
American Academy of Periodontology

• Tan SC, Patel BK, Jackson SH, Swift CG, Hutt AJ: Ibuprofen stereochemistry: double-
the-trouble? Enantiomer. 1999;4(3-4):195-203.

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