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Ibuprofen: Prepared by Nirozh Farhad Zamoo Mohammed

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation. It was discovered in 1961 and first marketed in the UK and US in the 1960s-70s under various trade names like Advil and Motrin. Ibuprofen works by reducing hormones that cause inflammation and pain. It is commonly used at dosages of 200-400 mg to treat conditions like headaches, toothaches, back pain, arthritis, and minor injuries, though high doses or long-term use may increase risks of heart attack, stroke, or stomach bleeding.

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44 views

Ibuprofen: Prepared by Nirozh Farhad Zamoo Mohammed

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation. It was discovered in 1961 and first marketed in the UK and US in the 1960s-70s under various trade names like Advil and Motrin. Ibuprofen works by reducing hormones that cause inflammation and pain. It is commonly used at dosages of 200-400 mg to treat conditions like headaches, toothaches, back pain, arthritis, and minor injuries, though high doses or long-term use may increase risks of heart attack, stroke, or stomach bleeding.

Uploaded by

nirozh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Ibuprofen

Prepared by
Nirozh Farhad
Zamoo mohammed
What is Ibuprofen
• Ibuprofen is a medication in the nonsteroidal anti-
inflammatory drug (NSAID) class that is used for treating pain,
fever, and inflammation.
• Ibuprofen was discovered in 1961 by Stewart Adams and
initially marketed as Brufen.
• It was first marketed in 1969 in the United Kingdom and in the
United States in 1974.
• It is available under a number of trade names, including Advil
and Motrin.
• It works by reducing hormones that cause inflammation and
pain in the body.
Chemistry of Ibuprofen

Structure:

(S)-ibuprofen (R)-ibuprofen
Preparation of Ibuprofen

Boots Group
Green Chemistry
Pharmacokinetics

• After oral administration, peak serum


concentration is reached after 1–2 hours and up
to 99% of the drug is bound to plasma proteins.
[49] The majority of ibuprofen is metabolised
and eliminated within 24 hours in the urine;
however, 1% of the unchanged drug is removed
through biliary excretion.
Ibuprofen Dosage
• Applies to the following strengths: 100 mg/5 mL; 800 mg; 300
mg; 600 mg; 400 mg; 200 mg; 50 mg/1.25 mL; 50 mg; 100 mg;
10 mg/mL; 100 mg/mL; 800 mg/200 mL
• The most commun is 200 mg and 400 mg
• Maximum dose: 3200 mg/day
• Dosage time change with the type of use
Use of Ibuprofen

• Ibuprofen is used to reduce fever and


treat pain or inflammation caused by
many conditions such as headache,
toothache, back pain, arthritis,
menstrual cramps, or minor injury
Ibuprofen side effects
• Ibuprofen can increase your risk of fatal
heart attack or stroke, especially if you use
it long term or take high doses, or if you
have heart disease. 
• Ibuprofen may also cause stomach or
intestinal bleeding
Thanks for your
attention

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