CC2 Pre-test 10.

Which of the following enzymes does not belong to

the class of enzymes known as the hydrolases?
1. It is the only anion that serves as an enzyme activator: A. Amylase
A. Inorganic phosphorus B. Lipase
B. Bicarbonate C. Alkaline phosphatase
C. Chloride D. Aldolase
D. Potassium
11. Which of the following will cause a shift of the oxygen
2. Which of the following enzymes is most useful in dissociation curve to the right, resulting in a decreased
establishing the hepatic origin of an elevated serum affinity of hemoglobin for 02?
alkaline phosphatase? A. Low plasma pH level
A. 5'-Nucleotidase B. Low PCO2 level
B. Alanine aminotransferase C. Low concentration of 2,3-biphosphoglycerate
C. Aspartate aminotransferase D. Low temperature
D. Lactate dehydrogenase
12. Which condition results in metabolic acidosis with
3. Which of the following is the most potent estrogen and severe hypokalemia and chronic alkaline urine?
is considered to the true ovarian hormone? A. Diabetic ketoacidosis
A. Estriol B. Phenformin-induced acidosis
B. Estrone C. Renal tubular acidosis
C. 17B-Estradiol D. Hyperaldosteronism
D. 16a-hydroxyesterone
13. The bilirubin fraction that is covalently attached to
4. Which of the following is the reference electrode used albumin and contributes to the conjugated bilirubin
for PO2 determination? value is:
A. Clark electrode A. Direct bilirubin
B. Severinghaus electrode B. Indirect bilirubin
C. Gas electrode C. Delta bilirubin
D. Calomel electrode D. Total bilirubin

5. All of the following chromogens will produce a colored 14. Which of the following mechanisms is responsible for
complex with iron that can be measured metabolic acidosis?
spectrophotometrically, except: A. Bicarbonate deficiency
A. 8-hydroxyquinoline B. Excessive retention of dissolved CO2
B. Ferrozine C. Bicarbonate excess
C. Bathophenanthroline D. Excessive excretion of dissolved CO2
D. Tripyridyl triazine
15. The appearance of the LD-1/LD-2 flipped pattern
6. Which equation illustrates the effect of substrate and the presence of the CK-MB isoenyzme on
concentration on The velocity of the enzyme catalyzed electrophoresis is highly suggestive of:
reaction? A. Acute pancreatitis
A. Bronsted and Lowry B. Cirrhosis
B. Michaelis-Menten C. Muscular dystrophy
C. Emil-Fischer D. Myocardial infarction
D. Nernst
16. Which reagent is used in the Jendrassik-Grof method
7. It is the most common drugs of abuse. to solubilize unconjugated bilirubin?
A. Ethanol A. 50% methanol
B. Amphetamines B. Butanol
C. Cannabinoid C. Caffeine-sodium-benzoate
D. Cocaine D. Ascorbic acid

8. Which of the following disorders is characterized by

increased production of chloride in sweat? 17. What is the immediate precursor of bilirubin
A. Cystic fibrosis formation?
B. Wilson's disease A. Urobilinogen
C. Multiple myeloma B. Biliverdin
D. Multiple sclerosis C. Mesobilirubinogen
D. Verdohemoglobin
9. It causes red-man syndrome:
A. Vancomycin
B. Aminoglycoside
C. Chloramphenicol
D. None of the above 18. In a patient with suspected primary hyperthyroidism
associated with Grave's disease, one would expect the
following laboratory serum results: free thyroxine D. Manganese
(FT4)____
thyroid hormone binding ratio (THBR)____ 27. Which of the following processes is part of the
and thyroid stimulating hormone (TSH)____ normal metabolism of bilirubin?
A.Increased, decreased, increased A. Both conjugated and unconjugated bilirubin are excreted
B. Increased, decreased, decreased into the bile
C. Increased, increased, decreased B. Methene bridges of bilirubin are reduced by intestinal
D. Decreased, decreased, increased bacteria forming urobilinogen
C. Most of the bilirubin delivered into the intestine is
19. Insecticides that are organic phosphorus compounds, reabsorbed
such as parathion and tetraethyl pyrophosphate, may D. Bilirubin and urobilinogen reabsorbed from the intestine
cause insecticide poisoning by inhibiting: are mainly excreted by the kidneys
A. Lactate dehydrogenase
B. Amylase 28. Which of the following is another name for vitamin
C. Acid phosphatase B12?
D. Cholinesterase A. Cyanocobalamin
B. Riboflavin
20. Which of the following condition is most likely to C. Retinol
produce elevated plasma potassium? D. Pyridoxine
A. Hypoparathyroidism
B. Hypoaldosteronism 29. Which of the following would be elevated in the blood
C. Hyperaldosteronism in medullary carcinoma of the thyroid?
D. Hyperparathyroidism A. Calcitonin
B. Thyroxine
21. Which of the following methods utilizes fructose-1, 6- C. Catecholamines
diphosphate as the substrate to form D. Secretin
Dihydroxyacetone phosphate?
A. Sibley-Lehninger method 30. Which of the following has an effect on plasma
B. Wrobleuski-Ladue method calcium levels?
C. Tanzer-Gilbarg method A. Potassium
D. Wacker method B. Chloride
C. Sodium
22. Which of the following membranes are employed in D. Phosphate
ISE for sodium determination?
A. Glass aluminum silicate 31. What condition is characterized by an elevation of
B. Valinomycin total bilirubin primarily due to an increase the
C. Silver wire coated with AgCl conjugated bilirubin? 
D. Vancomycin A. Hemolytic jaundice
B. Neonatal jaundice
23. It is the solute that contributes most to total serum C. Crigler-Najjar syndrome
osmolarity? D. Obstructive jaundice
A. BUN
B. Glucose 32. When continuous monitoring method is employed
C. Sodium during ACP determination, which of the following
D. Potassium substrate is preferred?
A. Thymolphthalein monophosphate
24. Of which of the following is 5-hydroxyindoleacetic B. a-naphthyl phosphate
acid (5-HIAA) trife primary metabolite? C. Phenyl phosphate
A. Epinephrine D. p-nitrophenylphosphate
B. Norepinephrine
C. Serotonin 34. Which of the following constituents normally present
D. Prolactin in serum must be chemically eliminated so that it will not
interfere with the measurement of serum magnesium?
25. When measuring enzyme activity, if the instrument is A. Iron
operating 5 C lower than the temperature prescribed for B. Potassium
the method. How will the results be affected? C. Calcium
A. Lower than expected D. Chloride
B. Higher than expected
C. Varied, showing no particular pattern 35. Which of the following proteins binds ferric ion and
D. All will be clinically important is increased in iron deficiency anemia?
A. Ferritin
26. Which of the following trace elements can be used for B. Hemosiderin
the treatment of Wilson's disease? C. Transferrin
A. Zinc D. Ceruloplasmin
B. Iron
C. Copper
36. Which statement regaraing total and direct Bilirubin A. Atomic absorption
levers is true? B. Colored anions precipitation
A. Total bilirubin level is a less sensitive and specific C. Flame emission
marker of liver disease than the direct level D. Dialysis method coupled with spectrophotometric
B. Direct bilirubin exceeds 3.5 mg/dL in most cases of analysis
hemolytic anemia
C. Direct bilirubin is normal in cholestatic liver disease 46. What does the concentration of urinary free cortisol
D. The ratio of direct to total bilirubin exceeds 0.40 in mainly reflect?
hemolytic anemia A. Total serum cortisol
B. Conjugated cortisol
37. Which of the following catalyzes the reverse CK C. Unbound serum cortisol
reaction that converts creatine phosphate to creatine? D. Protein-bound serum cortisol
A. Tanzer-Gilbarg Method
B. Wrobleuski-Ladue Method 47. Which of the following LDH isoenzyme-tissue
C. Wacker Method location is incorrectly paired?
D. Oliver-Rosalki Method A. LD 1- Liver
B. LD 2 - Red blood cells
38. All of the following factors may adversely affect the C. LD 3 - spleen
accurate quantification of bilirubin serum except:  D. LD 5 - Skeletal muscle
A. Lipemia
B. Hemolysis 48. Which of the following enzymes can be detected in
C. Exposure to light amniotic fluid for assessment of neural tube defects such
D. Specimen refrigeration as spina bifida and anencephaly?
A. Acetylcholinesterase
39. Which condition is caused by deficient secretion of B. Alkaline phosphatase
bilirubin into the bile canaliculi? C. Amylase
A. Gilbert's disease D. HCG
B. Neonatal hyperbilirubinemia
C. Dubin-Johnson syndrome 49. Which of the following enzymes is useful in
D. Crigler-Najar syndrome diagnosing hepatobiliary obstructive disorders?
A. Alkaline phosphatase
40. During electrophoresis, which of the following B. Alanine aminotransferase
isoenzymes of creatine kinase migrates the fastest on the C. Gamma-glutamyl transferase
anode region? D. Lactate dehydrogenase
A. CK-BB
B. CK-MB 50. In AMI, LD levels begin to rise within____, reach
C. CK-MM peak level within______and may remain elevated
D. Mitochondrial CK for____
A. 4-8 hours; 12-24 hours; 48-72 hours
41. It is used for the treatment of manic-depressive B. 12-24 hours; 48-72 hours; 10 days
illness (bipolar disorders). C. 6-8 hours; 24 hours; 5 days
A. Prozac D. 12-24 hours; 48-72 hours; 15 days
B. Lithium
C. Amitriptyline
D. Theophylline

42. Which of the following enzymes is responsible for the

conjugation of bilirubin?
A. UDP-glucurony| transferase
B. Alkaline phosphatase
C. Glutamate dehydrogenase
D. Leucine aminopeptidase

44. The major action of angiotensin II is:

A. Increased pituitary secretion of vasopressin
B. Increased vasoconstriction
C. Increased parathyroid hormone secretion by parathyroid
gland
D. Decreased adrenal secretion of aldosterone

45. The method that is the most sensitive and accurate

for determining serum and urine calcium level is: