SAFETY DATA SHEET

Creation Date 15-Apr-2009 Revision Date 24-Dec-2021 Revision Number 5

1. Identification
Product Name Ethyl ether

Cat No. : E134-1; E134-20; E134-4

CAS No 60-29-7
Synonyms Ethyl ether; Ether

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Fisher Scientific Company
One Reagent Lane
Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300

CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 1

Acute oral toxicity Category 4
Specific target organ toxicity (single exposure) Category 3
Target Organs - Respiratory system, Central nervous system (CNS).
Specific target organ toxicity - (repeated exposure) Category 2
Target Organs - Liver.
Aspiration Toxicity Category 1

Label Elements

Signal Word
Danger

Hazard Statements
Extremely flammable liquid and vapor
Harmful if swallowed

______________________________________________________________________________________________

Page 1 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

May cause respiratory irritation

May cause drowsiness or dizziness
May be harmful if swallowed and enters airways
May cause damage to organs through prolonged or repeated exposure

Precautionary Statements
Prevention
Wash face, hands and any exposed skin thoroughly after handling
Do not eat, drink or smoke when using this product
Do not breathe dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Wear protective gloves/protective clothing/eye protection/face protection
Keep cool
Response
Get medical attention/advice if you feel unwell
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician if you feel unwell
Skin
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Ingestion
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
Rinse mouth
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store in a well-ventilated place. Keep container tightly closed
Store locked up
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
May form explosive peroxides
Repeated exposure may cause skin dryness or cracking

3. Composition/Information on Ingredients
Component CAS No Weight %
Ethyl ether 60-29-7 >95

4. First-aid measures
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get

______________________________________________________________________________________________

Page 2 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention.

Inhalation Remove to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth
method if victim ingested or inhaled the substance; give artificial respiration with the aid of a
pocket mask equipped with a one-way valve or other proper respiratory medical device. Get
medical attention.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like
effects headache, dizziness, tiredness, nausea and vomiting
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media CO 2, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used to cool
closed containers.

Unsuitable Extinguishing Media Water may be ineffective

Flash Point -45 °C / -49 °F

Method - No information available

Autoignition Temperature 160 °C / 320 °F

Explosion Limits
Upper 36.0 vol %
Lower 1.9 vol %
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Extremely flammable. Risk of ignition. Vapors may travel to source of ignition and flash back. Vapors may form explosive mixtures
with air. Containers may explode when heated. May form explosive peroxides. Vapors may form explosive mixtures with air.

Hazardous Combustion Products

Carbon monoxide (CO). Carbon dioxide (CO2). peroxides.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA
Health Flammability Instability Physical hazards
1 4 1 N/A

6. Accidental release measures

Personal Precautions Use personal protective equipment as required. Remove all sources of ignition. Take
precautionary measures against static discharges. Avoid contact with skin, eyes or clothing.
Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological
Information.

Methods for Containment and Clean Remove all sources of ignition. Soak up with inert absorbent material. Take precautionary
Up measures against static discharges. Keep in suitable, closed containers for disposal. Use
spark-proof tools and explosion-proof equipment.

______________________________________________________________________________________________

Page 3 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

7. Handling and storage

Handling Wear personal protective equipment/face protection. Handle under an inert atmosphere.
Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Do not breathe
mist/vapors/spray. Keep away from open flames, hot surfaces and sources of ignition. If
peroxide formation is suspected, do not open or move container. Use only non-sparking
tools. Use spark-proof tools and explosion-proof equipment. Take precautionary measures
against static discharges. To avoid ignition of vapors by static electricity discharge, all metal
parts of the equipment must be grounded.

Storage. Flammables area. Store under an inert atmosphere. Keep away from open flames, hot
surfaces and sources of ignition. May form explosive peroxides. Containers should be dated
when opened and tested periodically for the presence of peroxides. Should crystals form in
a peroxidizable liquid, peroxidation may have occurred and the product should be
considered extremely dangerous. In this instance, the container should only be opened
remotely by professionals. Keep away from heat, sparks and flame. Keep container tightly
closed in a dry and well-ventilated place. Incompatible Materials. Strong oxidizing agents.
Strong acids.

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Ethyl ether TWA: 400 ppm (Vacated) TWA: 400 ppm IDLH: 1900 ppm TWA: 400 ppm
STEL: 500 ppm (Vacated) TWA: 1200 mg/m3 STEL: 500 ppm
(Vacated) STEL: 500 ppm
(Vacated) STEL: 1500
mg/m3
TWA: 400 ppm
TWA: 1200 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations
and safety showers are close to the workstation location. Use explosion-proof
electrical/ventilating/lighting equipment.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties

Physical State Liquid
Appearance Colorless
Odor aromatic

______________________________________________________________________________________________

Page 4 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

Odor Threshold No information available

pH No information available
Melting Point/Range -116 °C / -176.8 °F
Boiling Point/Range 34.6 °C / 94.3 °F
Flash Point -45 °C / -49 °F
Evaporation Rate 37.5
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 36.0 vol %
Lower 1.9 vol %
Vapor Pressure 587 mbar @ 20 °C
Vapor Density 2.55
Specific Gravity 0.714
Solubility Slightly soluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 160 °C / 320 °F
Decomposition Temperature No information available
Viscosity 0.2448 cP at 20 °C
Molecular Formula C4 H10 O
Molecular Weight 74.12

10. Stability and reactivity

Reactive Hazard Yes

Stability May form explosive peroxides. Air sensitive. Light sensitive. Hygroscopic.

Conditions to Avoid Incompatible products. Heat, flames and sparks. Exposure to air. Exposure to light.
Exposure to moisture. Keep away from open flames, hot surfaces and sources of ignition.

Incompatible Materials Strong oxidizing agents, Strong acids

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), peroxides

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions May form explosive peroxides.

11. Toxicological information

Acute Toxicity

Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Ethyl ether 1215 mg/kg (Rat) 20 mL/kg (Rabbit) 32000 ppm ( Rat ) 4 h

Toxicologically Synergistic No information available

Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation No information available

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Ethyl ether 60-29-7 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects Mutagenic effects have occurred in experimental animals.

______________________________________________________________________________________________

Page 5 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Respiratory system Central nervous system (CNS)

STOT - repeated exposure Liver

Aspiration hazard No information available

Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,
delayed tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects See actual entry in RTECS for complete information.

12. Ecological information

Ecotoxicity
Do not empty into drains.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Ethyl ether Not listed LC50: > 10000 mg/L, 96h EC50 = 5600 mg/L 15 min EC50 = 165 mg/L/24h
static (Lepomis macrochirus)
LC50: = 2560 mg/L, 96h
flow-through (Pimephales
promelas)

Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log Pow

Ethyl ether 0.82

13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes

Ethyl ether - 60-29-7 U117 -

14. Transport information

DOT
UN-No UN1155
Proper Shipping Name Diethyl ether
Hazard Class 3
Packing Group I
TDG
UN-No UN1155
Proper Shipping Name Diethyl ether
Hazard Class 3
Packing Group I
IATA
UN-No UN1155

______________________________________________________________________________________________

Page 6 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

Proper Shipping Name Diethyl ether

Hazard Class 3
Packing Group I
IMDG/IMO
UN-No UN1155
Proper Shipping Name Diethyl ether
Hazard Class 3
Packing Group I
15. Regulatory information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Ethyl ether 60-29-7 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Ethyl ether 60-29-7 X - 200-467-2 X X X X X KE-27690

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA - Occupational Safety and Not applicable

Health Administration

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Ethyl ether 100 lb -

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know

Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Ethyl ether X X X - X

______________________________________________________________________________________________

Page 7 / 8
Ethyl ether Revision Date 24-Dec-2021
______________________________________________________________________________________________

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product contains the following DHS chemicals:
Security Legend - STQs = Screening Threshold Quantities, APA = A placarded amount

Component DHS Chemical Facility Anti-Terrorism Standard

Ethyl ether Release STQs - 10000lb
Other International Regulations

Mexico - Grade Severe risk, Grade 4

Authorisation/Restrictions according to EU REACH

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Ethyl ether 60-29-7 Listed Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Ethyl ether 60-29-7 Not applicable Not applicable Not applicable Annex I - Y40 Annex I
- Y42

16. Other information

Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: EMSDS.RA@thermofisher.com

Creation Date 15-Apr-2009

Revision Date 24-Dec-2021
Print Date 24-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

______________________________________________________________________________________________

Page 8 / 8