Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER- 8 EXAMINATION — SUMMER -2023
Subject Code: BPSO1TT Date: 19/06/2023
Subject Name: Biostatistics and Research Methodology
Time:10.30 a.m. to 1.30 p.m. Total Marks: 80
Instructions:
. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q1 (a) What do you meant by Research? Explain experimental design techniques.

(b) Discuss- Histogram, Bar diagram.
(c) Explain chi square test for Goodness of fit.

Q2 (a) What do you mean by multiple regression, standard error of regression with
pharmaceutical examples.
(b) Explain cohort and cross sectional studies
(c) Write short note on ANOVA (Analysis of Variance).

Q3 (a) ‘What is meant by regression modelling? Explain hypothesis testing in simple

and multiple regression models.
(b) Explain student‘t’ test and its applications.
(0 Explain in detail of Probability, Binomial Distribution

Q4 (a) Explain regression analysis to assess the influence of independent variable on

continuous variable.
(b) How do you design a parallel group study?
(©) Explain: Central composite design

Q5 (a) Discuss briefly about determination of sample size for simple comparative
experiments and for confidence interval of specific width.
(b) What are “retrospective designs” in observational case studies, list its
advantages
(c) Explain curve fitting method of least square

(a) What is QbD, Why are DOE essential in a QbD development process?
(b) ‘What do you meant by factorial design? Write some advantages of factorial
design.
(c) What do you mean by industrial and clinical trial approach with suitable
examples
Q7 (a) Explain types of correlation and correlation coefficient. Give suitable examples.
(b) Discuss various phases in designing clinical trial with examples
(c) Classify Observational and experimental studies

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 Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B. Ph. - SEMESTER- VIII EXAMINATION — SUMMER -2022

Subject Code: BPS8O1TT Date: 31/05/2022

Subject Name: Biostatistics and Research Methodology
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Whatare parametric and non-parametric tests? Write a detailed note on 06
Correlation
(b) Write short not on cohort study. 05
(c) Enlist and Explain types of Significance tests in Statistics 05
Q.2 (a) Define following terms: 1) Variables 2) Graph 3) Sample Size 4) Statistics 06
5) Population 6) Hypothesis
(b) What do you mean by design of experiments? Write need ofdesign of 05
experiment.
(¢) Discuss Writing of report and presentation of data. 05

Q.3 (a) Whatis hypothesis? What are the different types of hypothesis? Explain howto 06
formulate hypothesis with suitable example.
(b) Explain different phases of clinical Trials. 05
(¢) Explain one way ANOVA and the assumptions in one way ANOVA. 05

Q4 (a) Define “t” test. Explain the different situation where paired and unpaired “t” 06
test is applied.
(b) Explain Probability and its significance in statistics. 05
(¢) Explain null hypothesis. Discuss error type-I and type-II 05
Q.5 (a) Explain the concept of Factorial design. 06
(b) Discuss histogram, Bar chart and pie chart. 05
(c) Discuss application of excel and SPPS programme in statistical analysis. 05

Q.6 (a) Theagesofthe 112 people who live on a tropical island are given below. 06
Age 0-9 | 10-19 | 20-29 | 30-39 | 40-49 | 50-59 | 60-69 | 70-79 | 80-89
Frequency | 20 | 21 23 16 11 10 & 8 1
Calculate the mean, median and mode.
(b) Classify different types of regression analysis. Discuss the least square method 05
in regression analysis
(¢) What is sampling? Explain in detail different methods of sampling 05
Q.7 (a) Find the value of the correlation coefficient from the following table: 06
Age 4312125425759
Glucose level |99 | 65|79 |75 |87 |81
(b) Define research. Write objective of research. Enlist types of research. 05
(c) Discuss the problems faced by researchers while attempting Empirical research. 05

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER-8 EXAMINATION - WINTER -2023
Subject Code: BPSO1TT Date: 01/12/2023
Subject Name: Biostatistics and Research Methodology
Time:02.30 p.m. to 5.30 p.m. Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define mean, Median and Mode. Comment: Median can express data 06
efficiently then mean when data are not normally distributed.
(b) Calculate average particle size from given data. 05
Particle size () | 8 9 10 11 12 13 14
No. of Particles | 12 21 35 42 29 11
(c) Enlist types of frequency distribution. Explain any one in detail. 05

Q.2 (a) Explain correlation with a suitable example. 06

(b) Discuss method of least squares. Give its applications and limitations. 05
(c¢) Differentiate: Normal Distribution and Poisson’s Distribution. 05
Q.3 (a) Define null hypothesis. Discuss types of error. 06
(b) Explain terms: i) Standard Error of Mean ii) Population 05
(¢) Calculate Standard deviation and Standard Error for given data of tablet 05
crushing strengths: 8, 6,7,8,9,8,6,8,7,8,7,9,6,7,9,7

Q.4 (a) Explain probability with example of tossig 3 coins and probability of all 06
possible occurances.
(b) Data of heart rate before and after exercise are given below. Using t-test state 05
whether exercise has any effect on heart rate or not?
Heart | Before |71 |75 |73 |71 |73 |74 |72 |75 |73
Rate | After 78 |81 |80 [79 |77 [82 |83 |81 |78
(t©.05,17) = 2.11, t0.0s, 18) = 2.10, t0.05,9) = 2.30, t.05,9) = 2.26)
(c) Differentiate One Way ANOVA and Two Way ANOVA 05

Q.5 (a) Give your Comments: 06

i) t-calculated must always be greater than t-tabulated for acceptable
results of an experiment
ii) Rejecting null hypothesis shows failure of experiment in parametric
tests.
(b) Compare Parametric tests and Non Parametric tests. 05
(c) Data for smoking and blood pressure are given below. Check whether both are 05
associated with each other or not.
Non Moderate | Chain
Smokers | Smoker Smokers
High Blood Pressure 95 111 126
No High Blood Pressure | 55 39 24
s.009=11.1 X2.009=599 x1.005= 3.84 6,005 = 12.6

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Q6 (a) Explain Pie Charts, Histogram and Contour Plots in brief. 06
(b) Discuss confounding with reference to fractional factorial designs. 05
(© Write a note on Full factorial designs. 05
Q7 (a) What are rotatable designs? Discuss central composite designs. 06
(b) Write a note on cohort studies. 05
(© Derive model for given data of 2* full factorial design. 05
X |X |Y
1 /-1 |-1 |8
2 |1 -1 13
3 1-1 1 6
4 |1 1 11

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm. — SEMESTER VIII EXAMINATION — WINTER-2022
Subject Code:BPSO1TT Date:09/01/2023
Subject Name: Biostatistics and Research Methodology
Time: 0 30PM TO 05:30PM Total Marks: 80
Instructions:
1 Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q1 (a) Explain correlation, type of correlation and its application in research. 06

(b) Explain the following terms:
a) Biostatistics
b) Arithmetic mean
c) Dispersion
d) Frequency distribution
e) Range
() The weight of 10 tablets is given below (in mg). Calculate the mean, median 05
and mode.
520, 525, 530, 510, 525, 535, 540, 510, 515, 525
Q2 (a) ‘Write a note on probability sampling techniques.
(b) ‘What are probabilities? Explain normal distribution.
(©) Define Standard deviation. Calculate the standard deviation of following
sample data:
10, 12, 14, 16, 20, 24, 28, 30
Q3 (a) ‘What is regression analysis? Explain in detail least square method for
regression analysis.
(b) Describe the following:
a) Standard error of mean
b) Quota sampling
(c) Define t-test and explain different type of t-tests.
Q4 (a) ‘What are parametic tests? Explain in detail about the one way ANOVA.
(b) Explain Wilcoxon Rank sum test and Friedman test.
(c) Discuss Histogram and Pie chart.

Q5 (a) ‘What is research? Explain in detail experimental design techniques.

(b) Write a short note on research report.
(©) Explain in detail cohorts and experimental studies.

(a) Write a note on blocking and confounding for two level factorial design.
(b) Explain the central composite design.
(c) Write a note on hypothesis testing in simple regression model.

Q7 (a) Define factorial design. Write a note on 2° factorial design.

(b) Write the importance of SPSS and MIN ITAB software in clinical trials.
(c) Explain the following:
a) Null hypothesis and alternative hypothesis
b) Type — I error and Type - II error

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